Lenvatinib
Trade name: Lenvima™

Lenvatinib is the generic for the trade name drug Lenvima™. In some cases, health care professionals may use the trade name Lenvima™ when referring to the generic drug name lenvatinib.

Drug type: Lenvatinib is a targeted therapy. It is an oral receptor tyrosine kinase inhibitor

What this drug is used for:
  • For the treatment of patients with locally recurrent or metastatic, progressive, radioactive iodine-refractory differentiated thyroid cancer.

Note: If a drug has been approved for one use, physicians may elect to use this same drug for other problems if they believe it may be helpful.

How this drug is given:
  • Lenvatinib is a pill, taken by mouth, once daily. It can be taken with or without food.
  • Take lenvatinib exactly as prescribed.
  • Swallow lenvatinib capsules whole. Do not crush, dissolve or open capsules.
  • Do not change your dose or stop lenvatinib unless your health care provider tells you to.
  • If you miss a dose, take it as soon as you remember. If your next dose is within 12 hours, skip the missed dose and take the next dose at your regular time.
  • Do not take more than 1 dose of lenvatinib at one time. Call your health care provider right away if you take too much.
  • The amount of lenvatinib that you will receive depends on many factors, your general health or other health problems, and the type of cancer or condition being treated.
  • Dose modifications are often made so it is important to let your healthcare provider know of any side effects.

Side effects:
Important things to remember about the side effects of lenvatinib:
  • Most people do not experience all of the side effects listed.
  • Side effects are often predictable in terms of their onset and duration.
  • There are many options to help minimize or prevent side effects.
  • There is no relationship between the presence or severity of side effects and the effectiveness of the medication.

The following side effects are common (occurring in greater than 30%) for patients taking lenvatinib:
  • High blood pressure
  • Diarrhea
  • Fatigue
  • Joint/muscle aches
  • Decreased appetite
  • Weight loss
  • Nausea
  • Stomatitis (mouth sores)
  • Headache
  • Vomiting
  • Proteinuria (protein in the urine)
  • Palmar-plantar erythrodysesthesia (hand-foot syndrome)
  • Abdominal pain
  • Dysphonia (difficulty speaking)