Adcetris
Generic Name: Brentuximab vedotin
Adcetris® is the trade name for the generic drug brentuximab vedotin. In some cases, health care professionals may use the generic name, brentuximab vedotin, when referring to the trade name, Adcetris®.

Drug type:Adcetris® is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. This medication is classified as an "­­­­­­­­­antineoplastic agent and a monoclonal antibody". (For more detail, see “How Adcetris® Works” below)

What Adcetris® Is Used For :
  • Treatment of adult patients with previously untreated stage III or IV classical Hodgkin lymphoma (cHL) in combination with chemotherapy.
  • Treatment of patients with Classical Hodgkin Lymphoma (cHL) at high risk of relapse or progression as post autologous hematopoietic stem cell transplantation (auto-HSCT) consolidation.
  • Treatment of patients with cHL after failure of auto-HSCT or after failure of at least two prior multi-agent chemotherapy regimens in patients who are not candidates for auto-HSCT.
  • Treatment of patients with systemic anaplastic large cell lymphoma after failure of at least one prior multi-agent chemotherapy regimen.
  • Treatment of patient with primary cutaneous anaplastic large cell lymphoma (pcALCL) or CD30-expressing mycosis fungoides (MF) who have received prior systemic therapy.

Note: If a drug has been approved for one use, physicians may elect to use this same drug for other problems if they believe it may be helpful.

How Adcetris® Is Given :
  • As an infusion into a vein (intravenous, IV) over 30 minutes.
  • The amount of Adcetris® that you will receive depends on many factors, including your weight, your general health or other health problems, and the type of cancer or condition you have. Your doctor will determine your exact dosage and schedule.

Adcetris® Side effects :
Important things to remember about the side effects of Adcetris® :
  • Most people will not experience all of the Adcetris® side effects listed.
  • Adcetris® side effects are often predictable in terms of their onset, duration, and severity.
  • Adcetris® side effects will improve after therapy is complete.
  • Adcetris® side effects may be quite manageable. There are many options to minimize or prevent the side effects of Adcetris®.

The following side effects are common (occurring in greater than 30%) for patients taking Adcetris® :
  • Low blood counts .
  • Peripheral neuropathy (numbness and tingling of the hands and feet)
  • Fatigue (feeling tired or weak)
  • Nausea
  • Diarrhea
  • Fever
  • Rash
  • Upper respiratory infection
  • Lung problems (if previously treated with bleomycin)